SELECTED PUBLICATIONS

On the technology by the scientists involved in Lauras

HIV:

Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients, FASEB J., 1998
http://www.fasebj.org/cgi/content/full/12/10/855

Additive effects of IL-2 and protein kinase A type I antagonist on function of T cells from HIV-infected patients on HAART.AIDS, 13:F109-14, 1999
http://www.aidsonline.com/pt/re/aids/fulltext.00002030-199912030-00001.htm

Cytokine networks are pre-activated in T cells from HIV-infected patients on HAART and are under the control of cAMP.AIDS, 2004
http://www.aidsonline.com/pt/re/aids/fulltext.00002030-200401230-00005.htm

and Editorial Comment in same issue of AIDS
http://www.aidsonline.com/pt/re/aids/fulltext.00002030-200401230-00025.htm

CVI (Common Variable Immunodeficiency):

Increased Activation of Protein Kinase A Type I Contributes to the T Cell Deficiency in Common
Variable Immunodeficiency, Journal of Immunology, 1999
http://www.jimmunol.org/cgi/content/full/162/2/1178

Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency – involvement of protein kinase A Type I. J. Immunol., 2003
http://www.jimmunol.org/cgi/content/full/170/11/5772

Mouse model disease (MAIDS):

Increased cAMP levels and protein kinase (PKA) type I activation in CD4+ T cells and B cells contribute to retrovirus-induced immunodeficiency of mice (MAIDS): a useful in vivo model for drug testing, FASEB J., 2001
http://www.fasebj.org/cgi/content/full/15/8/1466

Targeting COX-2:

Cyclooxygenase type 2-dependent prostaglandin E2 secretion is involved in retrovirus-induced T cell dysfunction in mice. Biochem. J., 2004.
http://www.biochemj.org/bj/384/0469/bj3840469.htm

Treatment with type-2 selective and non-selective cyclooxygenase inhibitors improves T-cell proliferation in HIV-infected patients on highly active antiretroviral therapy.n. AIDS, 2004.
http://www.aidsonline.com/pt/re/aids/fulltext.00002030-200404090-00015.htm

Immune modulatory effects of cyclooxygenase type 2 inhibitors in HIV patients on combination antiretroviral treatment. AIDS, 2006.
http://www.aidsonline.com/pt/re/aids/abstract.00002030-200604040-00004.htm

Molecular mechanisms and scientific basis:

Foxp3+ adaptive regulatory T cells express cycloxygenase type 2 and suppress T effector cells by a prostaglandin E2-dependent mechanism. J. Immunol, 2006.
http://www.jimmunol.org/cgi/content/full/177/1/246

The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages. J. Immunol, 2006.
http://www.jimmunol.org/cgi/content/full/176/12/7361

T cell receptor and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates T cell receptor signaling. J. Immunol., 2004.
http://www.jimmunol.org/cgi/content/full/173/8/4847

Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells. Eur. J. Immunol.
http://www3.interscience.wiley.com/cgi-bin/fulltext/109083474/HTMLSTART

Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling. J Biol Chem. 2003
http://www.jbc.org/cgi/content/full/278/20/17597

Protein kinase A intersects Src signaling in detergent membrane microdomains. J. Biol. Chem., 2003.
http://www.jbc.org/cgi/content/full/278/19/17170

A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIα. J. Biol. Chem., 2003.
http://www.jbc.org/cgi/content/full/278/19/17573

Inhibition of antigen specific T cell proliferation and cytokine production by PKA type I. J. Immunol. 2002
http://www.jimmunol.org/cgi/content/full/169/2/802

Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, Journal of Experimental Medicine, 2001 http://www.jem.org/cgi/content/full/193/4/497

Release from tonic inhibition of T cell activation through transient displacement of c-terminal Src kinase (Csk) from lipid rafts. J.Biol. Chem., in press- accelerated publication, 2001
http://www.jbc.org/cgi/reprint/C100014200v1

Selective Activation of cAMP-dependent Protein Kinase Type I Inhibits Rat Natural Killer Cell Cytotoxicity, Journal of Biological Chemistry, 1997
http://www.jbc.org/cgi/content/full/272/9/5495

Cyclic AMP-dependent protein kinase in human B cells. Localization of the regulatory subunit RIa with the B cell antigen receptor during B cell activation. European Journal of Immunolology, 26:1290-1296, 1996
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=8647207

Location of cAMP-dependent protein kinase type I with the TCR/CD3 complex. Science, 263:84-87, 1994
http://www.sciencemag.org/cgi/reprint/263/5143/84

Reviews:

Role of cAMP phosphodiesterase type 4 in regulation of T cell function. Crit. Rev. Immunol., 2006
No link yet available

Negative regulation of T-cell receptor activation by the cAMP-PKA-Csk signalling pathway in T-cell lipid rafts. Front. Biosci., 2006.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16720365

The molecular machinery for cAMP-dependent immunomodulation in T cells. Biochem. Soc. Transact., 2006.
http://www.biochemsoctrans.org/bst/034/0476/bst0340476.htm

Localised effects of cAMP mediated by distinct routes of Protein Kinase A. Physiological Rev.2004.
http://physrev.physiology.org/cgi/content/full/84/1/137

Positive and negative regulation of T cell activation by kinases and phosphatases. Biochem. J., 2003.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12485116

Protein kinase A type I as a potential target for therapeutic intervention. Drug News Perspect 13: 12-18, 2000
http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summaryn_pr?p_JournalId=3&p_RefId=659137

Molecular mechanisms for protein kinase A-mediated inhibition of immune function. Cell. Signalling, 2001
http://www.sciencedirect.com/...

Specificity in the cAMP/PKA signaling pathway. Differential expression, regulation, and subcellular localization of subunits of PKA, Frontiers in Bioscience, 2000
http://www.bioscience.org/2000/v5/d/skalhegg/list.htm